For anyone looking to get the most out of their kratom, both medicinally and cost-wise, it is a good idea to try to keep tolerance as low as possible. This will make kratom much more potent and help increase the effects over time. I’ve been doing some research on kratom tolerance and I’ve found a few ways to keep it low.
One of the best ways to keep your kratom tolerance low is to take different strains regularly. There are a few reasons that this can be helpful, but the main reason is because the alkaloid content of each different type of kratom is different. Because tolerance occurs when blood-brain levels of specific alkaloids stay too sustained for too long, the body responds by increasing density of the receptors the specific alkaloids effect.
When you decide to rotate strains, you are not allowing the alkaloid levels to remain stable or high enough to develop a full tolerance, although some tolerance will still develop. The best way to do this is to make sure that strains on different days and doses are as different as possible. Over time, this can reduce kratom tolerance and will let one feel the unique differences between different strains in a much more pronounced way.
Something else that I have heard is good for tolerance is magnesium. This is a supplement commonly used to treat reduce opiate tolerance, and as kratom acts upon the same receptors, and tolerance is regulated by NMDA receptors, magnesium can keep the brain from developing tolerance. The combination of these two techniques can dramatically reduce kratom tolerance long-term.
Although I’m sure there are a variety of other ways to reduce tolerance, there currently seem to be the most effective and safe for long-term reduction.